The rapid rise of international collaborative science has enabled access to genomic data. In this article, it is argued that to move beyond mapping genomic variation to understanding its role in complex disease aetiology and treatment will require extending data sharing for the purposes of clinical research translation and implementation.

Supererogation has gained attention as a means of explaining the voluntary behaviours of individuals and organizations that are done for the benefit of others and which go above what is required of legislation and what may be expected by society. Whilst the emerging literature has made some significant headway in exploring supererogation as an ethical lens for the study of business there remain several important issues that require attention. These comprise, the lack of primary evidence upon which such examinations have (...) been made, attention has been given to only singular pro-social acts of organizations, and the focus has been upon the actions of large organizations. Furthermore, Heyd’s (Supererogation, Cambridge University Press, 1982) original taxonomy of six supererogatory acts, comprising Moral Heroism, Beneficence, Volunteering, Favour, Forgiveness and Forbearance, has been considered to be complete and other forms of supererogatory acts have not yet been explored. In order to address these gaps this study poses the research questions: First, it studies how a single, contemporary SME performs multiple supererogatory acts in its attempts to address its social and environmental goals that go beyond CSR. Second, it seeks to gain a deeper theoretical understanding of Heyd’s (Supererogation, Cambridge University Press, 1982) taxonomy of six forms of supererogation through the capture of primary data. This research makes a three-year case study examination of a single SME that has been formally recognized for its work in addressing social and environmental issues at local, national and global levels. Primary data are acquired of the supererogatory acts that it performs through a three-year participant observation case study, utilizing 61 interviews and 3 focus groups with internal and external stakeholders. In doing so, it addresses the empirical limitations of the extant research, substantiates each of the forms that supererogatory acts may take, and makes a contribution to the theory of supererogation by identifying a further class of act that is ‘Sharing’. (shrink)

Aim: Patients with advanced cancer need information about end-of-life treatment options in order to make informed decisions. Clinicians vary in the frequency with which they initiate these discussions.Patients and methods: As part of a long-term longitudinal study, patients with an expected 2-year survival of less than 50% who had advanced gastrointestinal or lung cancer or amyotrophic lateral sclerosis were interviewed. Each patient’s medical record was reviewed at enrollment and at 3 months for evidence of the discussion of patient wishes concerning (...) ventilator support, artificial nutrition and hydration , resuscitation and hospice care. A Kaplan–Meier analysis was also performed and 2-year survival calculated.Results: 60 cancer and 32 ALS patients were enrolled. ALS patients were more likely than cancer patients to have evidence of discussion about their wishes for ventilator support , ANH , DNR and hospice care . At 6 months, 91% of ALS patients were alive compared with 62% of cancer patients; at 2 years, 63% of ALS patients were alive compared with 23% of cancer patients .Conclusions: Cancer patients were less likely than ALS patients to have had documented advanced care planning discussions despite worse survival. This may reflect perceptions that ALS has a more predictable course, that advanced cancer has a greater number of treatment options, or differing views about hope. Nevertheless, cancer patients may be less adequately prepared for end-of-life decision-making. (shrink)

In this article, Lucas maintains the falseness of Mechanism - the attempt to explain minds as machines - by means of Incompleteness Theorem of Gödel. Gödel’s theorem shows that in any system consistent and adequate for simple arithmetic there are formulae which cannot be proved in the system but that human minds can recognize as true; Lucas points out in his turn that Gödel’s theorem applies to machines because a machine is the concrete instantiation of a formal system: therefore, for (...) every machine consistent and able of doing simple arithmetic, there is a formula that it can’t produce as true but that we can see to be true, and so human minds and machines have to be different. Lucas considers as well in this article some possible objections to his argument: for any Gödelian formula we could, for instance, construct a machine able to produce it or we could put the Gödelian formulae that we had proved as axioms of a further machine. However - as Lucas underlines - for every of such machines we could again formulate another Gödelian formula, the Gödelian formula of these machines, that they are not able to proof but that we can recognize as true. More general arguments, such as the possibility to escape Gödelian argument by suggesting that Gödel’s theorem applies to consistent systems while we could be inconsistent ones, are moreover refuted by Lucas by maintaining that our inconsistency corresponds to occasional malfunctioning of a machine and not to his normal inconsistency; indeed, a inconsistent machine is characterized by producing any statement, on the contrary human being are selective and not disposed to assert anything. (shrink)

v. 1. Nicomachean ethics. Politics. The Athenian Constitution. Rhetoric. On Poetics.--v. 2. Logic.--v. 3. Physics. Metaphysics. On the soul. Short physical treaties.--v. 4. On the heavens. On generation and corruption. Meteorology. Biological treatises.

PLoS ONE 3(3): e1897. doi:10.1371/journal.pone.

The philosophical problem of knowledge of other minds is rational justifiction. this paper covers n malcolm, h h price, j mill, strawson, hamshire, l wittgenstein and a j ayer's controversial thought. philosophical scepticism holds that it is logically impossible to know mental experiences. "i know, i have a pain." how do i know that other people also can have similar pain? it provides as ideal knowledge of mental events. when i say, "i have a pain," i can have certain knowledge (...) of this because i have conclusive individual evidence for it. (shrink)

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

Having defined a notion of homology for paired graphs, Métayer ([Ma]) proves a homological correctness criterion for proof nets, and states that for any proof net \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $G$\end{document} there exists a Jordan-Hölder decomposition of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} ${\mathsf H}_0(G)$\end{document}. This decomposition is determined by a certain enumeration of the pairs in \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $G$\end{document}. We correct his (...) proof of this fact and show that there exists a 1-1 correspondence between these Jordan-Hölder decompositions of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} ${\mathsf H}_0(G)$\end{document} and the possible ‘construction-orders’ of the par-net underlying \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document} $G$\end{document}. (shrink)

The legend of the encounter between Wilberforce and Huxley is well established. Almost every scientist knows, and every viewer of the BBC's recent programme on Darwin was shown,* how Samuel Wilberforce, bishop of Oxford, attempted to pour scorn on Darwin's Origin of Species at a meeting of the British Association in Oxford on 30 June 1860, and had the tables turned on him by T. H. Huxley. In this memorable encounter Huxley's simple scientific sincerity humbled the prelatical insolence and clerical (...) obscurantism of Soapy Sam; the pretension of the Church to dictate to scientists the conclusions they were allowed to reach were, for good and all, decisively defeated; the autonomy of science was established in Britain and the Western world; the claim of plain unvarnished truth on men's allegiance was vindicated, however unwelcome its implications for human vanity might be; and the flood tide of Victorian faith in all its fulsomeness was turned to an ebb, which has continued to our present day and will only end when religion and superstition have been finally eliminated from the minds of all enlightened men. Even churchmen concede that it was a disastrous defeat.1 Only Owen Chadwick strikes a note of caution, observing that the account given of the incident in Wilberforce's biography seems hardly consistent with an overwhelming defeat, and maintaining that the received account must be a largely legendary creation of a later date. (shrink)

There was once a leak from Hebdomadal Council. The Assessor told her husband, who told my wife, who told me that Monday afternoon had been spent discussing what Lucas would say if various courses of action were adopted, leading to the conclusion that it would be best to do nothing. I was flattered, but a bit surprised. The tide of philosophical scepticism had ebbed, and it was generally allowed that a reasonable way of discovering what someone would say was to (...) ask him. Dick Southwood did: he would quiz me in Common Room – sometimes ending "Thank you for letting me bounce these ideas off you" – and had reliable information about how one member of Congregation would react to various proposals. And not only me: he was a listening Vice-Chancellor, who used to bike from Wellington Square to Merton for lunch, greeting many as he passed them, and ready to stop if occasion warranted it. Of course, there are many other leaks. I remember once attending a meeting in the Town Hall to argue for cycle tracks, and someone coming up to me, and saying, "You’re having a tussle with Council, aren’t you? I think you ought to see the minutes of their latest meeting"; the next day there was a copy in my pigeon hole, giving me just the ammunition I needed. What members of Congregation tend the forget is the existence – the other side of the green baize door, so to speak – of a corps of bedells. (shrink)

R T Allen; The Meaning of Life and Education, Journal of Philosophy of Education, Volume 25, Issue 1, 30 May 2006, Pages 47–58, https://doi.org/10.1111/j.1467-9.

R T Allen; The Meaning of Life and Education, Journal of Philosophy of Education, Volume 25, Issue 1, 30 May 2006, Pages 47–58, https://doi.org/10.1111/j.1467-9.

In 1885, during initial discussions of J. C. Maxwell's celebrated thermodynamic demon, Whiting (1) observed that the demon-like velocity selection of molecules can occur in a gravitationally bound gas. Recently, a gravitational Maxwell demon has been proposed which makes use of this observation [D. P. Sheehan, J. Glick, and J. D. Means, Found. Phys. 30, 1227 (2000)]. Here we report on numerical simulations that detail its microscopic phase space structure. Results verify the previously hypothesized mechanism of its paradoxical behavior. This (...) system appears to be the only example of a fully classical mechanical Maxwell demon that has not been resolved in favor of the second law of thermodynamics. (shrink)